We study how life adapts its metabolism — across cells, organisms, and evolutionary time.
Investigating molecular mechanisms from single cells to whole organisms using the cavefish Astyanax mexicanus.
Astyanax
Model Organism
~20,000 yrs
Evolutionary Divergence
T2D & Liver
Human Health Insights
Bioinspired metabolism
& aging.
Our research focuses on understanding the molecular mechanisms that shape metabolic landscapes — from individual cells to whole organisms. We investigate how animals adapt to extreme metabolic challenges, illuminating natural solutions to human health.
Looking for detailed protocols & experimental paradigms?
Explore our complete methodologies, dietary models, and lab facility.
Astyanax mexicanus
The Mexican tetra is an extraordinary natural evolutionary experiment. Two distinct morphs of the exact same species — ancestral surface dwellers and derived subterranean cavefish — offer unprecedented insight into metabolic adaptation.
Why Study Natural Metabolic Extremes?
Cave populations evolved elevated body fat storage, remarkable starvation resistance, and persistent hyperglycemia without developing the microvascular or organ pathologies observed in human type 2 diabetes. By understanding these natural protective mechanisms, our lab illuminates novel therapeutic targets for metabolic disease and aging.
Selected Publications.
Peer-reviewed discoveries probing metabolic plasticity, fatty liver health, and comparative biology.
Mentorship & Student Research
Undergraduate and graduate researchers conducting feeding trials and behavioral assays with Dr. Cobham.
Inclusive & Collaborative Science.
The Cobham Lab is committed to building an environment where everyone belongs. We value diverse perspectives, open collaboration, and mutual support. Lab members are encouraged to ask questions, take intellectual risks, and celebrate each other's growth as scientists and as people.
We hold regular lab meetings, journal clubs, and one-on-ones to support every member's development and ensure that science in our lab is rigorous, reproducible, and joyful.
Science Without Borders.
From local Panhandle mentorship to international capacity-building with TReND in Africa, we believe science thrives through open doors and mutual empowerment.
Join the Lab.
The Cobham Lab is growing. We are looking for enthusiastic graduate students, undergraduate researchers, and postdoctoral scholars excited about metabolic biology, evolutionary genetics, and model organism research.
Graduate Students
We are actively recruiting motivated graduate students interested in metabolic biology, evolutionary genetics, and model organism research.
Undergraduate Researchers
WTAMU undergraduates are welcome to inquire about research opportunities. No prior experience required — curiosity is enough.